38.11 Red cell folate

Red cell folate data available for STOP cohort only.


38.11.1 Global tests

Type III ANOVA on main and interaction effects, and LM model summaries.

PRL (ng/ml)
Chisq Df Pr(>Chisq)
(Intercept) 40.028499 1 <0.0001 ***
ns(rcfolate, 3) 1.960676 3 0.6 ns
GA_samp 6.148700 1 0.01 *
hPL (μg/ml)
Chisq Df Pr(>Chisq)
(Intercept) 1.0424502 1 0.3 ns
ns(rcfolate, 3) 0.7310778 3 0.9 ns
GA_samp 249.6341984 1 <0.0001 ***
GH2 (ng/ml)
Chisq Df Pr(>Chisq)
(Intercept) 23.962818 1 <0.0001 ***
ns(rcfolate, 3) 3.481161 3 0.3 ns
GA_samp 77.928194 1 <0.0001 ***
Insulin (uU/ml)
model term df1 df2 F.ratio Chisq p.value
rcfolate 1 Inf 0.121 0.121 0.7 ns
GA_samp 1 Inf 0.050 0.050 0.8 ns
HOMA-IR
model term df1 df2 F.ratio Chisq p.value
rcfolate 1 Inf 0.102 0.102 0.7 ns
GA_samp 1 Inf 0.012 0.012 0.9 ns
Glucose (mmol/L)
model term df1 df2 F.ratio Chisq p.value
rcfolate 1 Inf 0.169 0.169 0.7 ns
GA_samp 1 Inf 0.010 0.010 0.9 ns

38.11.2 Model summary

Ratio of Geometric means (95% CI)

PRL (ng/ml)
Var Effect P
(Intercept) 54.20 (15.88, 184.71) <0.0001
ns(rcfolate, 3)1 0.65 (0.28, 1.48) 0.30
ns(rcfolate, 3)2 0.26 (0.04, 1.76) 0.17
ns(rcfolate, 3)3 1.13 (0.77, 1.65) 0.53
GA_samp 1.09 (1.02, 1.16) 0.01
hPL (μg/ml)
Var Effect P
(Intercept) 1.48 (0.70, 3.12) 0.31
ns(rcfolate, 3)1 0.88 (0.53, 1.46) 0.63
ns(rcfolate, 3)2 0.90 (0.27, 2.93) 0.86
ns(rcfolate, 3)3 0.92 (0.74, 1.15) 0.47
GA_samp 1.38 (1.33, 1.44) <0.0001
GH2 (ng/ml)
Var Effect P
(Intercept) 0.09 (0.04, 0.24) <0.0001
ns(rcfolate, 3)1 0.88 (0.46, 1.74) 0.69
ns(rcfolate, 3)2 1.58 (0.03, 7.29) 0.55
ns(rcfolate, 3)3 0.81 (0.39, 1.06) 0.13
GA_samp 1.26 (1.19, 1.32) <0.0001
Insulin (uU/ml)
Var Effect P
(Intercept) 11.50 (2.61, 50.72) 0.001
ns(rcfolate, 3)1 1.44 (0.59, 3.51) 0.42
ns(rcfolate, 3)2 1.85 (0.23, 15.03) 0.56
ns(rcfolate, 3)3 1.23 (0.75, 2.03) 0.41
GA_samp 1.01 (0.92, 1.11) 0.82
HOMA-IR
Var Effect P
(Intercept) 2.66 (0.49, 14.34) 0.26
ns(rcfolate, 3)1 1.44 (0.51, 4.07) 0.49
ns(rcfolate, 3)2 1.85 (0.16, 21.90) 0.62
ns(rcfolate, 3)3 1.20 (0.70, 2.06) 0.51
GA_samp 1.01 (0.91, 1.11) 0.91
Glucose (mmol/L)
Var Effect P
(Intercept) 4.74 (3.47, 6.47) <0.0001
ns(rcfolate, 3)1 1.02 (0.81, 1.28) 0.88
ns(rcfolate, 3)2 1.08 (0.64, 1.84) 0.77
ns(rcfolate, 3)3 0.96 (0.89, 1.04) 0.30
GA_samp 1.00 (0.99, 1.02) 0.92

38.11.3 Diagnostics

Model diagnositcs.

Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)

38.11.4 Plots