38.11 Red cell folate

Red cell folate data available for STOP cohort only.

38.11.1 Global tests

Type III ANOVA on main and interaction effects, and LM model summaries.

PRL (ng/ml)

	Chisq	Df	Pr(>Chisq)
(Intercept)	40.028499	1	<0.0001	***
ns(rcfolate, 3)	1.960676	3	0.6	ns
GA_samp	6.148700	1	0.01	*

hPL (μg/ml)

	Chisq	Df	Pr(>Chisq)
(Intercept)	1.0424502	1	0.3	ns
ns(rcfolate, 3)	0.7310778	3	0.9	ns
GA_samp	249.6341984	1	<0.0001	***

GH2 (ng/ml)

	Chisq	Df	Pr(>Chisq)
(Intercept)	23.962818	1	<0.0001	***
ns(rcfolate, 3)	3.481161	3	0.3	ns
GA_samp	77.928194	1	<0.0001	***

Insulin (uU/ml)

model term	df1	df2	F.ratio	Chisq	p.value
rcfolate	1	Inf	0.121	0.121	0.7	ns
GA_samp	1	Inf	0.050	0.050	0.8	ns

HOMA-IR

model term	df1	df2	F.ratio	Chisq	p.value
rcfolate	1	Inf	0.102	0.102	0.7	ns
GA_samp	1	Inf	0.012	0.012	0.9	ns

Glucose (mmol/L)

model term	df1	df2	F.ratio	Chisq	p.value
rcfolate	1	Inf	0.169	0.169	0.7	ns
GA_samp	1	Inf	0.010	0.010	0.9	ns

38.11.2 Model summary

Ratio of Geometric means (95% CI)

PRL (ng/ml)

Var	Effect	P
(Intercept)	54.20 (15.88, 184.71)	<0.0001
ns(rcfolate, 3)1	0.65 (0.28, 1.48)	0.30
ns(rcfolate, 3)2	0.26 (0.04, 1.76)	0.17
ns(rcfolate, 3)3	1.13 (0.77, 1.65)	0.53
GA_samp	1.09 (1.02, 1.16)	0.01

hPL (μg/ml)

Var	Effect	P
(Intercept)	1.48 (0.70, 3.12)	0.31
ns(rcfolate, 3)1	0.88 (0.53, 1.46)	0.63
ns(rcfolate, 3)2	0.90 (0.27, 2.93)	0.86
ns(rcfolate, 3)3	0.92 (0.74, 1.15)	0.47
GA_samp	1.38 (1.33, 1.44)	<0.0001

GH2 (ng/ml)

Var	Effect	P
(Intercept)	0.09 (0.04, 0.24)	<0.0001
ns(rcfolate, 3)1	0.88 (0.46, 1.74)	0.69
ns(rcfolate, 3)2	1.58 (0.03, 7.29)	0.55
ns(rcfolate, 3)3	0.81 (0.39, 1.06)	0.13
GA_samp	1.26 (1.19, 1.32)	<0.0001

Insulin (uU/ml)

Var	Effect	P
(Intercept)	11.50 (2.61, 50.72)	0.001
ns(rcfolate, 3)1	1.44 (0.59, 3.51)	0.42
ns(rcfolate, 3)2	1.85 (0.23, 15.03)	0.56
ns(rcfolate, 3)3	1.23 (0.75, 2.03)	0.41
GA_samp	1.01 (0.92, 1.11)	0.82

HOMA-IR

Var	Effect	P
(Intercept)	2.66 (0.49, 14.34)	0.26
ns(rcfolate, 3)1	1.44 (0.51, 4.07)	0.49
ns(rcfolate, 3)2	1.85 (0.16, 21.90)	0.62
ns(rcfolate, 3)3	1.20 (0.70, 2.06)	0.51
GA_samp	1.01 (0.91, 1.11)	0.91

Glucose (mmol/L)

Var	Effect	P
(Intercept)	4.74 (3.47, 6.47)	<0.0001
ns(rcfolate, 3)1	1.02 (0.81, 1.28)	0.88
ns(rcfolate, 3)2	1.08 (0.64, 1.84)	0.77
ns(rcfolate, 3)3	0.96 (0.89, 1.04)	0.30
GA_samp	1.00 (0.99, 1.02)	0.92

38.11.3 Diagnostics

Model diagnositcs.

Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)

38.11.4 Plots